Differentiating between Central Nervous System Lymphoma and High-grade Glioma Using Dynamic Susceptibility Contrast and Dynamic Contrast-enhanced MR Imaging with Histogram Analysis.

作者: Kazuhiro Murayama , Yuya Nishiyama , Yuichi Hirose , Masato Abe , Shigeharu Ohyu

DOI: 10.2463/MRMS.MP.2016-0113

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摘要: Purpose We evaluated the diagnostic performance of histogram analysis data from a combination dynamic susceptibility contrast (DSC)-MRI and contrast-enhanced (DCE)-MRI for quantitative differentiation between central nervous system lymphoma (CNSL) high-grade glioma (HGG), with aim identifying useful perfusion parameters as objective radiological markers differentiating them. Methods Eight lesions CNSLs 15 HGGs who underwent MRI examination, including DCE DSC-MRI, were enrolled in our retrospective study. DSC-MRI provides corrected cerebral blood volume (cCBV), DCE-MRI transfer coefficient (Ktrans) plasma to extravascular extracellular space. Ktrans cCBV measured round region-of-interest slice maximum size on lesion. The differences t values CNSL HGG determining most appropriate percentile investigated. Ktrans, cCBV, Ktrans/cCBV investigated using analysis. Receiver operating characteristic (ROC) ratio was performed. Results 30th (C30) 80th (C80) percentiles distinguishing values. showed significantly lower C80 higher C30 Ktrans/C80 than those HGG. In ROC analysis, had best discriminative value compared or cCBV. Conclusion by found reveal characteristics vascularity permeability lesion more precisely either alone. Histogram these vascular microenvironments enabled

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