Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain.
作者： Jakob Seidlitz , Jonathan O’Muircheartaigh , Ralica Dimitrova , Daphna Fenchel , Antonios Makropoulos
DOI: 10.1371/JOURNAL.PBIO.3000976
关键词:
摘要: Interruption to gestation through preterm birth can significantly impact cortical development and have long-lasting adverse effects on neurodevelopmental outcome. We compared morphology captured by high-resolution, multimodal magnetic resonance imaging (MRI) in n = 292 healthy newborn infants (mean age at 39.9 weeks) with regional patterns of gene expression the fetal cortex across (n 156 samples from 16 brains, aged 12 37 postconceptional weeks [pcw]). tested hypothesis that noninvasive measures structure mirror areal differences gestation, a cohort 64 32.0 weeks), we whether alterations observed after were associated altered specific developmental cell populations. Neonatal was aligned differential cell-specific cortex. Principal component analysis (PCA) 6 microstructure showed regions ordered along principal axis, primary clearly separated heteromodal This axis correlated estimated tissue maturity, indexed genes expressed progenitor cells neurons, engaged stem differentiation, neuron migration, forebrain development. Preterm MRI metrics glial The spatial patterning developing thus mirrored variation term, this disrupted birth. work provides framework link molecular mechanisms early life highlights novel pathways injury neonatal populations increased risk disorder.
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