Persistent Changes in Gene Expression Induced by Estrogen and Progesterone in the Rat Mammary Gland

作者: Melanie R. Ginger , Maria F. Gonzalez-Rimbau , Jason P. Gay , Jeffrey M. Rosen

DOI: 10.1210/MEND.15.11.0724

关键词:

摘要: Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize the hormonal milieu present during results in persistent changes pattern of gene expression mammary gland, leading to permanent cell fate determine subsequent proliferative response gland. To investigate this hypothesis, we used suppression subtractive hybridization identify genes are persistently up-regulated glands E- and progesterone (P)-treated Wistar-Furth rats 28 d after steroid hormone treatment compared with age-matched virgins. Using approach, a number displaying altered previous E P were identified. Two markers been characterized greater detail: RbAp46 novel specifies noncoding RNA (designated G.B7). Both lobules regressed gland required both for maximal expression. has implicated complexes involving chromatin remodeling, suggesting mechanism whereby epigenetic factors responsible may be related determination fate. These provide first support at molecular level hypothesis hormone-induced involuted

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