Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand.

摘要: Background Although zidovudine prophylaxis decreases the rate of transmission human immunodeficiency virus (HIV) type 1 substantially, a large number infants still become infected. We hypothesized that administration, in addition to zidovudine, single dose oral nevirapine mothers during labor and neonates would further reduce HIV. Methods conducted randomized, double-blind trial three treatment regimens Thai women who were receiving therapy third trimester pregnancy. In one group, received (nevirapine–nevirapine regimen); another, placebo, respectively (nevirapine–placebo last, placebo (placebo–placebo regimen). The also week formula-fed. end point study was infection with HIV infants, established by virologic testi...