Whole body protein synthesis and turnover in normal man and malnourished patients with and without known cancer.

摘要: Plateau enrichment of 15N-ammonia following 24 hour continuous intravenous infusion 15N-glycine was used to measure total body protein turnover and synthesis in normal volunteers malnourished patients, with without cancer. The mean postabsorptive rate three controls 2.5 g protein/kg/day. Protein decreased by a 23% one week fasting, returned baseline levels refeeding. In patients known tumor, whole similar controls; seven ten days parenteral nutrition (TPN) the nontumor-bearing 18%. Three tumors had marked elevations turnover; TPN increased five This study suggests that some malignant can increase both fed state. may represent direct effect or reflect concomitant illness.