Role of the Amygdala in Antidepressant Effects on Hippocampal Cell Proliferation and Survival and on Depression-like Behavior in the Rat

摘要: The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted other brain areas received much less attention. basolateral complex amygdala (BLA), a region involved in anxiety and site action antidepressants, implicated both basal stress-induced changes neural plasticity dentate gyrus. We investigated here whether BLA modulates effects SSRI antidepressant fluoxetine on cell proliferation survival relation to behavioral index depression-like behavior (forced swim test). used lesion approach targeting along chronic treatment fluoxetine, monitored levels given important role this trait progress depression. Chronic had positive effect only when was lesioned. Anxiety related opposite ways sham- BLA-lesioned animals (i.e., negatively positively animals). Both lesions low were critical factors enable negative relationship between behavior. Therefore, our study highlights for fluoxetine-stimulated establishment link It also reveals an modulatory involving BLA-dependent -independent mechanisms. Our findings underscore as target modulate antidepressants' their behaviors.