Association between rectal optical signatures and colonic neoplasia: potential applications for screening.

摘要: Field carcinogenesis detection represents a promising means for colorectal cancer (CRC) screening, although current techniques (e.g., flexible sigmoidoscopy) lack the requisite sensitivity. The novel optical technology low-coherence enhanced backscattering (LEBS) spectroscopy, allows identification of microscale architectural consequences field in preclinical CRC models with unprecedented accuracy. To investigate potential clinical translatability this approach, we obtained biopsies from normal-appearing rectal mucosa patients undergoing colonoscopy (n = 219). LEBS signals were recorded through bench-top instrument. Four parameters characterizing signal linearly combined into single marker. We found that generally mirrored neoplasia progression no neoplasia, to 5 9 mm adenoma and advanced adenomas. composite marker calculated paralleled risk status (ANOVA P < 0.001). Moreover, was independent factors, benign colonic findings, or clinically unimportant lesions (diminutive adenomas, hyperplastic polyps). For had sensitivity 100%, specificity 80%, area under receiver operator characteristic curve 0.895. Leave-one-out cross-validation an data set 51) supported robustness these findings. In conclusion, provide first demonstration LEBS-detectable alterations endoscopically normal rectum associated presence located elsewhere colon. This study provides proof concept analysis may potentially minimally intrusive screening technique. Further studies compatible fiber optic probe are way multicenter validation.