CXCL5 promotes mitomycin C resistance in non-muscle invasive bladder cancer by activating EMT and NF-κB pathway.
作者： Chanjuan Wang , Aiwei Li , Shuo Yang , Rui Qiao , Xi Zhu
DOI: 10.1016/J.BBRC.2018.03.071
关键词:
摘要: Abstract The emergence of chemoresistance greatly increases the recurrence risk for non-muscle invasive bladder cancer (NMIBC) patients, which is still a big concern clinicians. Understanding mechanisms drug resistance great significance preventing and reversing it. We showed here that CXC motif chemokine ligand 5 (CXCL5) was overexpressed in mitomycin C-resistant cell line M-RT4. Meanwhile, parental RT4 treated with recombinant human CXCL5 (rhCXCL5) reduced its sensitivity to C. Conversely, knockdown sensitized M-RT4 cell. further investigated molecular finding epithelial mesenchymal transition (EMT) NF-κB pathway were activated cell, could be attenuated by CXCL5. All these data indicated may promote activating EMT pathway. Thus, our study identifies as novel chemoresistance-related marker NMIBC, thereby providing new strategies overcome NMIBC patients.
sci-hub.se 参考文章(27)
Lu G, Xiong X, Guo H, Liu S, Dong J, Establishment of doxorubicin-resistant human bladder cancer cell line (BUI-87/ADMR) and its mechanism of multidrug resistance. Chinese Medical Journal. ,vol. 110, pp. 167- 172 ,(1997)
YE GAO, ZHENFENG GUAN, JIAQI CHEN, HONGJUN XIE, ZHAO YANG, JINHAI FAN, XINYANG WANG, LEI LI, CXCL5/CXCR2 axis promotes bladder cancer cell migration and invasion by activating PI3K/AKT-induced upregulation of MMP2/MMP9 International Journal of Oncology. ,vol. 47, pp. 690- 700 ,(2015) , 10.3892/IJO.2015.3041
Abhisek Mitra, Lopa Mishra, Shulin Li, EMT, CTCs and CSCs in tumor relapse and drug-resistance Oncotarget. ,vol. 6, pp. 10697- 10711 ,(2015) , 10.18632/ONCOTARGET.4037
Samy Lamouille, Jian Xu, Rik Derynck, Molecular mechanisms of epithelial–mesenchymal transition Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 178- 196 ,(2014) , 10.1038/NRM3758
Hae-Yun Jung, Laurent Fattet, Jing Yang, Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis Clinical Cancer Research. ,vol. 21, pp. 962- 968 ,(2015) , 10.1158/1078-0432.CCR-13-3173
Alberto Mantovani, Inflaming metastasis Nature. ,vol. 457, pp. 36- 37 ,(2009) , 10.1038/457036B
Haiyang Zhang, Hongxiu Ning, Lia Banie, Guifang Wang, Guiting Lin, Tom F Lue, Ching-Shwun Lin, None, Adipose Tissue-Derived Stem Cells Secrete CXCL5 Cytokine with Chemoattractant and Angiogenic Properties Biochemical and Biophysical Research Communications. ,vol. 402, pp. 560- 564 ,(2010) , 10.1016/J.BBRC.2010.10.090
M Saxena, M A Stephens, H Pathak, A Rangarajan, Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters Cell Death & Disease. ,vol. 2, pp. e179- e179 ,(2011) , 10.1038/CDDIS.2011.61
Jiajia Zheng, Xi Zhu, Jie Zhang, CXCL5 knockdown expression inhibits human bladder cancer T24 cells proliferation and migration Biochemical and Biophysical Research Communications. ,vol. 446, pp. 18- 24 ,(2014) , 10.1016/J.BBRC.2014.01.172
S L Kunkel, S B Morris, Y Y Xue, M D Burdick, M C Glass, M D Iannettoni, R M Strieter, D A Arenberg, M P Keane, B DiGiovine, Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. Journal of Clinical Investigation. ,vol. 102, pp. 465- 472 ,(1998) , 10.1172/JCI3145