Capturing adenylyl cyclases as potential drug targets

摘要: Cyclic AMP (cAMP) is an important intracellular signalling mediator. It generated in mammals by nine membrane-bound and one soluble adenylyl cyclases (ACs), each with distinct regulation expression patterns. Although many drugs inhibit or stimulate AC activity through the respective upstream G-protein coupled receptors (for example, opioid beta-adrenergic receptors), ACs themselves have not been major drug targets. Over past decade studies on physiological functions of different mammalian isoforms as well advances development isoform-selective inhibitors activators suggest that could be useful Here we discuss therapeutic potential compounds various clinical settings, including neuropathic pain, neurodegenerative disorders, congestive heart failure, asthma male contraception.