Using peptidyl aldehydes in activity-based proteomics.
作者： Eduard Sabidó , Teresa Tarragó , Ernest Giralt
DOI: 10.1016/J.BMCL.2009.04.148
关键词:
摘要: The broad inhibitory spectrum of aldehydes and the possibility that amino acid residues modulate their specificity point to potential using peptidyl as activity-based probes. Here, we establish in proteomics by synthesizing different probes them specifically label a well-known serine protease an activity-dependent manner. From our results, emerge promising enable multiple enzymatic-class detection substrate recognition can be used diverse applications like protein identification activity profiling.
elsevier.com
sci-hub.se 参考文章(49)
A V Bakker, S Jung, R W Spencer, F J Vinick, W S Faraci, Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal. Biochemical Journal. ,vol. 271, pp. 559- 562 ,(1990) , 10.1042/BJ2710559
Yue-Ming Li, Min Xu, Ming-Tain Lai, Qian Huang, José L. Castro, Jillian DiMuzio-Mower, Timothy Harrison, Colin Lellis, Alan Nadin, Joseph G. Neduvelil, R. Bruce Register, Mohinder K. Sardana, Mark S. Shearman, Adrian L. Smith, Xiao-Ping Shi, Kuo-Chang Yin, Jules A. Shafer, Stephen J. Gardell, Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 Nature. ,vol. 405, pp. 689- 694 ,(2000) , 10.1038/35015085
Ingo Schulz, Bernd Gerhartz, Antje Neubauer, Andreas Holloschi, Ulrich Heiser, Mathias Hafner, Hans-Ulrich Demuth, Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition. FEBS Journal. ,vol. 269, pp. 5813- 5820 ,(2002) , 10.1046/J.1432-1033.2002.03297.X
Fernando Albericio, Ernest Giralt, Paul Lloyd-Williams, Chemical Approaches to the Synthesis of Peptides and Proteins ,(1997)
Elaine W. S. Chan, Souvik Chattopadhaya, Resmi C. Panicker, Xuan Huang, Shao Q. Yao, Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases. Journal of the American Chemical Society. ,vol. 126, pp. 14435- 14446 ,(2004) , 10.1021/JA047044I
Je-Tae Woo, Kohji Yamaguchi, Takahiro Hayama, Takeo Kobori, Sanae Sigeizumi, Kikuo Sugimoto, Kiyosi Kondo, Tomoko Tsuji, Yasuo Ohba, Kahori Tagami, Koji Sumitani, Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. European Journal of Pharmacology. ,vol. 300, pp. 131- 135 ,(1996) , 10.1016/0014-2999(95)00858-6
M. Bogyo, J. S. McMaster, M. Gaczynska, D. Tortorella, A. L. Goldberg, H. Ploegh, Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HslV by a new class of inhibitors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 6629- 6634 ,(1997) , 10.1073/PNAS.94.13.6629
Christian W. Tornøe, Caspar Christensen, Morten Meldal, Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Journal of Organic Chemistry. ,vol. 67, pp. 3057- 3064 ,(2002) , 10.1021/JO011148J
Daisuke Kato, Kelly M Boatright, Alicia B Berger, Tamim Nazif, Galia Blum, Ciara Ryan, Kareem A H Chehade, Guy S Salvesen, Matthew Bogyo, Activity-based probes that target diverse cysteine protease families Nature Chemical Biology. ,vol. 1, pp. 33- 38 ,(2005) , 10.1038/NCHEMBIO707
Sandor Bajusz, Erzsebet Szell, Daniel Bagdy, Eva Barabas, Gyula Horvath, Marianne Dioszegi, Zsuzsa Fittler, Gabriella Szabo, Attila Juhasz, Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H. Journal of Medicinal Chemistry. ,vol. 33, pp. 1729- 1735 ,(1990) , 10.1021/JM00168A030