Stacks of coaligned nanopores and fabrication and uses thereof

摘要: Disclosed is an improved form of nanopore-based molecular sensor: a stack coaligned nanopores in equivalent number directly stacked membranes. One or more the membranes moved laterally, altering volumetric shape and thus sensing characteristics passage. This allows at least three major improvements over existing nanopore sensors: 1) volumetrically tunable sensors allow wider range analyte sizes, 2) changes novel translocation control transiting molecules, enabling information to be derived from single molecules through interactions with walls passage controllable alterations local electrostratic hydrodynamic environment, 3) regeneration appropriate sensor geometry event corrosion clogging, greatly extending useful lifetime individual sensors.