Anti-invasive and anti-angiogenic compositions

摘要: A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant other chemical derivative thereof inhibits cell invasion, endothelial tube formation angiogenesis in vitro. number of variants and this peptide, preferably capped at N- C-termini, as well peptidomimetic derivatives, are useful for treating diseases conditions mediated by undesired uncontrolled invasion and/or angiogenesis. Pharmaceutical compositions comprising above peptides derivatives administered to subjects need such treatment dosage sufficient inhibit The disclosed methods particularly suppressing growth metastasis tumors.