Insomnia with objective short sleep duration is associated with deficits in neuropsychological performance: a general population study.

摘要: INSOMNIA IS THE MOST COMMON SLEEP DISORDER, YET LITTLE KNOWN ABOUT MECHANISMS, CAUSES, CLINICAL COURSE, AND CONSEQUENCES of this highly prevalent chronic condition.1 Many studies have established that insomnia is comorbid with psychiatric disorders and a risk factor for the development depression, anxiety, suicide.2 However, evidence on association medical morbidity very limited.1,2 Although insomniacs commonly complain cognitive deficits, mainly attention concentration, there surprising lack to suggest link between dysfunction in objective testing.3–5 In fact, published reviews demonstrated poorer performance among patients only small number (approximately 10% 25%), according 2006 Standards Insomnia Committee. Thus they concluded no specific psychomotor or cognitive-performance measure can be recommended routine use studies.6 3 most recent studies,7–9 using polysomnography data compare normal sleepers, results were mixed. Two included sample sizes, whereas third relatively large group research volunteer primary used rather narrowly focused battery. To date, our largest population-based study full comprehensive neuropsychological battery has been conducted adults investigate performance. We previously reported short sleep duration may an index biological severity disorder. Specifically, shown associated high hypertension10 type 2 diabetes11 as well activation hypothalamic-pituitary-adrenal (HPA) axis.12–14 The latter finding particularly relevant because hyperactivity HPA axis neurocognitive deficits.15–18 Based these observations, we speculate at deficits performance. order test hypothesis, examined joint effects complaint cross-sectional from Penn State Cohort.