The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain.
作者： Andrew C. Peterson , Sheng Zhang , Sien Hu , Herta H. Chao , Chiang-shan R. Li
关键词:
摘要: Dysfunction of the dopaminergic ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) is implicated in psychiatric disorders including attention-deficit/ hyperactivity disorder (ADHD), addiction, schizophrenia movement such as Parkinson’s disease. Although prevalence these varies by age sex, underlying neural mechanism not well understood. The objective this study was to delineate distinct resting state functional connectivity (rsFC) VTA SNc examine effects age, from young middle-adulthood, sex on rsFC two structures a data set 250 healthy adults (18-49 years 104 men). Using blood oxygenation level dependent (BOLD) signals we compared time course courses all other brain voxels. At corrected threshold, paired t test showed stronger bilateral angular gyrus superior/middle orbital frontal regions insula, thalamus, parahippocampal amygdala. Compared women, men VTA/SNc left posterior gyrus. In linear regressions, but women age-related changes number cortical cerebellar regions. Supporting shared also cerebral gender differences middle adulthood connectivity, new findings help advance our understanding bases many neuropsychiatric illnesses that implicate systems.
frontiersin.org
core.ac.uk
mendeley.com参考文章(134)
S.A.R.B Rombouts, C.J Stam, J.P.A Kuijer, Ph Scheltens, F Barkhof, Identifying confounds to increase specificity during a “no task condition”: Evidence for hippocampal connectivity using fMRI NeuroImage. ,vol. 20, pp. 1236- 1245 ,(2003) , 10.1016/S1053-8119(03)00386-0
Cynthia Kuhn, Emergence of sex differences in the development of substance use and abuse during adolescence Pharmacology & Therapeutics. ,vol. 153, pp. 55- 78 ,(2015) , 10.1016/J.PHARMTHERA.2015.06.003
Ken-ichi Kinoshita, Yayoi Tada, Yoshikage Muroi, Toshihiro Unno, Toshiaki Ishii, Selective loss of dopaminergic neurons in the substantia nigra pars compacta after systemic administration of MPTP facilitates extinction learning Life Sciences. ,vol. 137, pp. 28- 36 ,(2015) , 10.1016/J.LFS.2015.07.017
MR DeLong, MD Crutcher, AP Georgopoulos, Relations between movement and single cell discharge in the substantia nigra of the behaving monkey The Journal of Neuroscience. ,vol. 3, pp. 1599- 1606 ,(1983) , 10.1523/JNEUROSCI.03-08-01599.1983
Jeremy D. Schmahmann, Deepak N. Pandya, Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey. The Journal of Neuroscience. ,vol. 17, pp. 438- 458 ,(1997) , 10.1523/JNEUROSCI.17-01-00438.1997
Walter Schulz-Schaeffer, Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson's Disease? Biomolecules. ,vol. 5, pp. 1467- 1479 ,(2015) , 10.3390/BIOM5031467
Alessandro Martorana, Giacomo Koch, "Is dopamine involved in Alzheimer's disease?". Frontiers in Aging Neuroscience. ,vol. 6, pp. 252- 252 ,(2014) , 10.3389/FNAGI.2014.00252
Adriene M. Beltz, Sheri A. Berenbaum, Stephen J. Wilson, Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence. Experimental and Clinical Psychopharmacology. ,vol. 23, pp. 247- 254 ,(2015) , 10.1037/PHA0000033
Sheng Zhang, Sien Hu, Herta H. Chao, Chiang-Shan R. Li, Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age Cerebral Cortex. ,vol. 26, pp. 3413- 3427 ,(2016) , 10.1093/CERCOR/BHV172
M. D. Fox, A. Z. Snyder, J. L. Vincent, M. Corbetta, D. C. Van Essen, M. E. Raichle, The human brain is intrinsically organized into dynamic, anticorrelated functional networks Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 9673- 9678 ,(2005) , 10.1073/PNAS.0504136102