Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection.

摘要: Staphylococcus epidermidis is a permanent member of the normal human microbiota, commonly found on skin and mucous membranes. By adhering to tissue surface moieties host via specific adhesins, S. capable establishing lifelong commensal relationship with humans that begins early in life. In its role as organism, thought provide benefits host, including out-competing more virulent pathogens. However, largely due capacity form biofilm implanted foreign bodies, has emerged an important opportunistic pathogen patients receiving medical devices. causes approximately 20% all orthopedic device-related infections (ODRIs), increasing up 50% late-developing infections. Despite this prevalence, it remains underrepresented scientific literature, particular lagging behind study aureus. This review aims overview interactions both pathogen. The mechanisms retained by enable colonization well invasive infection, will be described, focus upon formation. immune responses these are also how seems trigger low levels pro-inflammatory cytokines high interleukin-10, which may contribute sub-acute persistent nature often associated adaptive response poorly represents area significant new discoveries coming years.