Diagnosis and Treatment of Basal Cell and Squamous Cell Carcinoma

作者: Jonathon M. Firnhaber

DOI:

关键词:

摘要: Family physicians are regularly faced with identifying, treating, and counseling patients skin cancers. Nonmelanoma cancer, which encompasses basal cell squamous carcinoma, is the most common cancer in United States. Ultraviolet B exposure a significant factor development of carcinoma. The use tanning beds associated 1.5-fold increase risk carcinoma 2.5-fold Routine screening for controversial. U.S. Preventive Services Task Force cites insufficient evidence to recommend or against routine whole-body examination screen cancer. Basal commonly appears as pearly white, dome-shaped papule prominent telangiectatic surface vessels. Squamous firm, smooth, hyperkeratotic plaque, often central ulceration. Initial tissue sampling diagnosis involves shave technique if lesion raised, 2- 4-mm punch biopsy abnormal-appearing area skin. Mohs micrographic surgery has lowest recurrence rate among treatments, but best considered large, high-risk tumors. Smaller, lower-risk tumors may be treated surgical excision, electrodesiccation curettage, cryotherapy. Topical imiquimod fluorouracil also potential, less supported, treatments. Although there no clear guidelines follow-up after an index nonmelanoma monitoring prudent because subsequent 35 percent at three years 50 five years.

参考文章(34)
Douglas Torre, Continuing medical education (dermatologic surgery): cryosurgery of basal cell carcinoma Journal of The American Academy of Dermatology. ,vol. 15, pp. 917- 929 ,(1986) , 10.1016/S0190-9622(86)70251-X
Steven Kossard, Robert Rosen, Cutaneous Bowen's disease. An analysis of 1001 cases according to age, sex, and site. Journal of The American Academy of Dermatology. ,vol. 27, pp. 406- 410 ,(1992) , 10.1016/0190-9622(92)70208-W
Mack Sexton, Daniel B. Jones, Mary E. Maloney, Histologic pattern analysis of basal cell carcinoma Journal of the American Academy of Dermatology. ,vol. 23, pp. 1118- 1126 ,(1990) , 10.1016/0190-9622(90)70344-H
R. Motley, P. Kersey, C. Lawrence, Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma British Journal of Dermatology. ,vol. 146, pp. 18- 25 ,(2002) , 10.1046/J.0007-0963.2001.04615.X
Stanley J Miller, Murad Alam, James Andersen, Daniel Berg, Christopher K Bichakjian, Glen Bowen, Richard T Cheney, L Frank Glass, Roy C Grekin, Anne Kessinger, Nancy Y Lee, Nanette Liegeois, Daniel D Lydiatt, Jeff Michalski, William H Morrison, Kishwer S Nehal, Kelly C Nelson, Paul Nghiem, Thomas Olencki, Clifford S Perlis, E William Rosenberg, Ashok R Shaha, Marshall M Urist, Linda C Wang, John A Zic, None, Basal cell and squamous cell skin cancers. Journal of The National Comprehensive Cancer Network. ,vol. 8, pp. 836- 864 ,(2010) , 10.6004/JNCCN.2010.0062
S. Bakis, L. Irwig, G. Wood, D. Wong, Exfoliative cytology as a diagnostic test for basal cell carcinoma: a meta-analysis. British Journal of Dermatology. ,vol. 150, pp. 829- 836 ,(2004) , 10.1111/J.1365-2133.2004.05716.X
Timothy M. Johnson, Dan E. Rowe, Bruce R. Nelson, Neil A. Swanson, Squamous cell carcinoma of the skin (excluding lip and oral mucosa). Journal of The American Academy of Dermatology. ,vol. 26, pp. 467- 484 ,(1992) , 10.1016/0190-9622(92)70074-P
Juan-Carlos Martinez, Clark C. Otley, The management of melanoma and nonmelanoma skin cancer: a review for the primary care physician. Mayo Clinic proceedings. ,vol. 76, pp. 1253- 1265 ,(2001) , 10.4065/76.12.1253
Clay J. Cockerell, Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis"). Journal of The American Academy of Dermatology. ,vol. 42, pp. 11- 17 ,(2000) , 10.1067/MJD.2000.103344
Dale Lawrence Pearlman, Weekly pulse dosing: Effective and comfortable topical 5-fluorouracil treatment of multiple facial actinic keratoses Journal of The American Academy of Dermatology. ,vol. 25, pp. 665- 667 ,(1991) , 10.1016/0190-9622(91)70250-6