Prostate Cancer Burden at the Uganda Cancer Institute

作者: Fred Okuku , Jackson Orem , George Holoya , Chris De Boer , Cheryl L. Thompson

DOI: 10.1200/JGO.2015.001040

关键词:

摘要: PurposeIn Uganda, the incidence of prostate cancer is increasing at a rate 5.2% annually. Data describing presentation and outcomes for patients with are lacking.MethodsA retrospective review medical records men histologically confirmed Uganda Cancer Institute (UCI) from January 1 to December 17, 2012, was performed.ResultsOur sample included 182 whose mean age 69.5 years (standard deviation, 9.0 years). Patients who presented UCI had lower urinary tract symptoms (73%; n = 131), bone pain (18%; 32), increased prostate-specific antigen (PSA; 3%; 5), other (6%; 11). Median baseline PSA 91.3 ng/mL (interquartile range, 19.5-311.3 ng/mL), 51.1% (n 92) value above 100 ng/mL. Gleason score 9 or 10 in 66.7% 120). Ninety percent 136) stage IV disease, metastatic sites 102), viscera (21%; 29), lymph nodes (4%; 5)....

参考文章(10)
Folakemi T. Odedina, Flora A. M. Ukoli, J. Olufemi Ogunbiyi, Roots of prostate cancer in African-American men. Journal of The National Medical Association. ,vol. 98, pp. 539- 543 ,(2006)
Henry R. Wabinga, Sarah Nambooze, Phoebe Mary Amulen, Catherine Okello, Louise Mbus, Donald Maxwell Parkin, Trends in the incidence of cancer in Kampala, Uganda 1991–2010 International Journal of Cancer. ,vol. 135, pp. 432- 439 ,(2014) , 10.1002/IJC.28661
Folakemi T Odedina, Titilola O Akinremi, Frank Chinegwundoh, Robin Roberts, Daohai Yu, R Renee Reams, Matthew L Freedman, Brian Rivers, B Lee Green, Nagi Kumar, Prostate cancer disparities in Black men of African descent: a comparative literature review of prostate cancer burden among Black men in the United States, Caribbean, United Kingdom, and West Africa Infectious Agents and Cancer. ,vol. 4, pp. 1- 8 ,(2009) , 10.1186/1750-9378-4-S1-S2
Glenn R. Cunningham, Carol M. Ashton, John F. Annegers, Julianne Souchek, Marcella Klima, Brian Miles, Familial aggregation of prostate cancer in African‐Americans and white Americans The Prostate. ,vol. 56, pp. 256- 262 ,(2003) , 10.1002/PROS.10252
Lisa W. Chu, Jamie Ritchey, Susan S. Devesa, Sabah M. Quraishi, Hongmei Zhang, Ann W. Hsing, Prostate Cancer Incidence Rates in Africa Prostate Cancer. ,vol. 2011, pp. 947870- 947870 ,(2011) , 10.1155/2011/947870
S. H. Landis, T. Murray, S. Bolden, P. A. Wingo, Cancer statistics, 1998 CA: A Cancer Journal for Clinicians. ,vol. 48, pp. 6- 29 ,(1998) , 10.3322/CANJCLIN.48.1.6
Judd W. Moul, Thomas H. Douglas, William F. McCarthy, David G. McLeod, Black Race is an Adverse Prognostic Factor for Prostate Cancer Recurrence Following Radical Prostatectomy in an Equal Access Health Care Setting The Journal of Urology. ,vol. 155, pp. 1667- 1673 ,(1996) , 10.1016/S0022-5347(01)66160-3
Henrik Grönberg, Prostate cancer epidemiology. The Lancet. ,vol. 361, pp. 859- 864 ,(2003) , 10.1016/S0140-6736(03)12713-4
D Maxwell Parkin, Freddie Bray, Jacques Ferlay, Ahmedin Jemal, None, Cancer in Africa 2012 Cancer Epidemiology, Biomarkers & Prevention. ,vol. 23, pp. 953- 966 ,(2014) , 10.1158/1055-9965.EPI-14-0281
Elizabeth A Tindall, MS Riana Bornman, Smit van Zyl, Alpheus M Segone, L Richard Monare, Philip A Venter, Vanessa M Hayes, Addressing the contribution of previously described genetic and epidemiological risk factors associated with increased prostate cancer risk and aggressive disease within men from South Africa BMC Urology. ,vol. 13, pp. 74- 74 ,(2013) , 10.1186/1471-2490-13-74