Cell Membrane Capsules for Encapsulation of Chemotherapeutic and Cancer Cell Targeting in Vivo

摘要: Systemic administration of chemotherapeutic agents can cause indiscriminate drug distribution and severe toxicity. Until now, encapsulation targeting drugs have typically relied on synthetic vehicles, which cannot minimize the clearance by renal system may also increase risk chemical side effects. Cell membrane capsules (CMCs) provide a generic far more natural approach to challenges delivery in vivo. Here aptamer AS1411, recognize bind overexpressed nucleolin cancer cell membrane, was chemically conjugated onto CMCs. As result, AS1411 modified CMCs showed enhanced ingestion certain cells vitro accumulation mouse xenografts Chemotherapeutics contrast with therapeutically significant concentrations be packaged into reversible permeating their plasma membranes. The systematic loaded doxorubicin hydrochloride significantly inh...