Economic evaluation of ondansetron: Preliminary analysis using clinical trial data prior to price setting

摘要: This study combines secondary analysis of efficacy and side-effect data from a randomised controlled trial with estimates resource use to evaluate the likely economic effects new antiemetic agent ondansetron. Costs, cost-effectiveness ondansetron in prophylaxis acute nausea vomiting induced by chemotherapy are assessed relative therapy metoclopramide. Superior is quantified both terms significant emesis avoided management costs avoided. A simple cost analysis, metoclopramide dosage priced at 10 pounds, indicates that would give equivalent net treatment costs, price ratio (ondansetron/metoclopramide) 2.3 1. If therapeutic success defined as avoidance side-effects, then two therapies be equally cost-effective drug 5 We conclude that, (i) evaluation prior setting feasible informative; (ii) such models can indicate prospective collection priorities.