Applications of Biotechnology in Drug Discovery and Evaluation

摘要: As should be expected, a large portion of this volume has been dedicated to products that are presently available through various biotechnological processes (e.g., human insulin, tissue plasminogen activator, interferons, and monoclonal antibodies). These substances have either demonstrated or theoretical utility in the treatment disease conditions clearly will increasing impact on practice contemporary pharmacy. From pragmatic viewpoint, however, widespread clinical use these is generally limited by necessity parenteral administration. A direct method circumventing problem involves development novel drug-delivery systems (see Chapter 6, volume). An alternative approach defining structural conformational characteristics active region large-molecular-weight drugs then producing relatively small molecular weight analogues anticipated mediate similar biological responses 14,