Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice
作者： Xiaojun Liu , Shuguang Jiang , Chongyun Fang , Shiyu Yang , Devvora Olalere
DOI: 10.1158/0008-5472.CAN-15-0159
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摘要: Target-mediated toxicity is a major limitation in the development of chimeric antigen T-cell receptors (CAR) for adoptive cell therapy of solid tumors. In this study, we developed a …
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