作者: Joshua J Bayes , Harmit S Malik
DOI: 10.1002/9780470015902.A0020827
关键词:
摘要: Human centromeres are comprised of millions base pairs tandemly repeated deoxyribonucleic acid (DNA) sequences. Contrary to the expectation that centromeric sequences would be extremely constrained for centromere function throughout primate evolution, these represent some most rapidly evolving in genome. This rapid evolution spite conserved has been referred as ‘centromere paradox’, and it is hypothesized an ancient, ongoing genetic conflict at heart this evolution. Keywords: chromosome inheritance; mutation; molecular evolution; genetic conflict; epigenetics