Maternal and fetal lipid metabolism under normal and gestational diabetic conditions

摘要: Maternal lipids are strong determinants of fetal fat mass. Here we review the overall lipid metabolism in normal and gestational diabetes mellitus (GDM) pregnancies. During early pregnancy, increase maternal depots is facilitated by insulin, followed increased adipose tissue breakdown subsequent hypertriglyceridemia, mainly as a result insulin resistance (IR) estrogen effects. The response to variable greater IR but decreased levels. vast majority fatty acids (FAs) circulation esterified associated with lipoproteins. These taken up placenta hydrolyzed lipases. released FAs enter various metabolic routes into circulation. Although these modified GDM, fetus does not seem receive more than non-GDM Long-chain polyunsaturated essential for development obtained from mother. Mitochondrial FA oxidation occurs contributes energy production. Fetal accretion during last weeks gestation very rapidly sustained only crossing placenta, also lipogenesis. hyperinsulinemia GDM mothers promotes excess tissue, which gives rise altered adipocytokine profiles. lipoproteins low at birth, effects unclear. body neonates women risk factor obesity childhood later life.