Association of low-dose exposure to persistent organic pollutants with E-cadherin promoter methylation in healthy Koreans
作者： Ji Yun Lee , Kyung Min Lee , Duk Hee Lee , Dong Sun Kim
DOI: 10.1080/1354750X.2017.1417482
关键词:
摘要: AbstractBackground: Persistent organic pollutants (POPs), despite their considerably low levels in humans, are an increasing concern for the general populations given various adverse health problems, including metabolic and carcinogenic effects. DNA methylation deregulation is thought to be a key mechanism development of human chronic diseases cancer.Methods: In attempt identify biomarkers monitoring low-dose exposure hazard, we explored whether organochlorine pesticides (OCPs) polychlorinated biphenyls (PCBs) may influence tumour suppressor gene E-cadherin (CDH1) using peripheral blood cells from 364 healthy Korean subjects.Results: CDH1 was observed 78.3% study subjects. Serum concentrations OCPs or PCBs compounds were higher methylation-positive subjects than methylation-negative ones. After adjusting covariates, odds ratio summary measure 1.0, 2.5 (95% confide...
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