Human herpesvirus-6 meningoencephalitis in a recipient of an unrelated allogeneic bone marrow transplantation.

摘要: Background. Human herpesvirus-6 (HHV-6) has been implicated in bone marrow suppression, interstitial pneumonitis, and fatal meningoencephalitis transplant (BMT) recipients. Methods. We describe the case of a woman with acute myeloid leukemia second remission who developed febrile 8 months after unrelated BMT. Results. Computed tomography magnetic resonance images brain were nonspecific. Analysis cerebrospinal fluid (CSF) revealed lymphocytosis an increased protein level. Using polymerase chain reaction methods, HHV-6 was only pathogen detected CSF, peripheral blood mononuclear cells, marrow. The patient treated ganciclovir foscarnet for 3 months. All clinical manifestations resolved analysis CSF became negative 40 days beginning antiviral treatment. Conclusions. This observation strongly suggests that should be sought BMT patients neurological complications may respond to therapy.