Follow-Up of Atypical Prostate Needle Biopsies Suspicious for Cancer

摘要: Abstract Objectives. To determine both how the diagnosis of an atypical biopsy influences a urologist’s decision to repeat and outcome rebiopsy. Methods. Of 200 biopsies that we confirmed from outside consultations Johns Hopkins Hospital 1992 1993, were able retrieve follow-up information for 144 cases. Each was evaluated reason atypia (atrophic glands, rule out [r/o] adenosis, not otherwise specified [NOS; insufficient cytologic and/or architectural atypia], r/o prostatic intraepithelial neoplasia [PIN], inflammation, crush artifact) favored (cancerous, benign, undetermined). Results. biopsies, 92 rebiopsied (63.9%). The time initial rebiopsy ranged 0.5 months 3 years (63% less than 6 months; 39% months). Rebiopsy revealed carcinoma in 48.9%, benign 38%, 8.7%, PIN 4.4%. median prostate-specific antigen (PSA) value lower men who did undergo (6 versus 7.8) (rank sum analysis, P = 0.04). No correlation found between PSA level results which cancer favored, 61% cancerous on 33% where process favored. three reasons seemed correlate with NOS (68% rebiopsy); inflammation adenosis (36% rebiopsy). Conclusions. Although 48.9% cases cancerous, only 63% underwent rebiopsy, raising concern cancers are being missed those after diagnosis. there trend serum this significant, even 4 ng/mL had risk histologic features foci may be useful as factors determining urgency they also statistically significant predicting outcome. Men diagnoses should regardless levels why lesions atypical.