A Simple, Efficient Synthesis of N6-[bis(ethylamino) methylene]-N2-[(1,1-dimethylethoxy)carbonyl]-lysine (Boc-diethylhomoarginine)
作者： H. B. Arzeno , W. Bingenheimer , D. J. Morgans
DOI: 10.1080/00397919008051585
关键词:
摘要: Abstract The synthesis of N6-(bis(ethylamino)methylene]-N2-[(1,1-dimethyl ethoxycarbonyl] lysine (Boc-diethylhomoarginine) by regiospecific amidination with (ethylamino) (ethylimino)-methanesulfonic acid (2) is described.
informaworld.com参考文章(9)
Audrey E. Miller, Daniel J. Feeney, Yan Ma, Lyn Zarcone, M. A. Aziz, E. Magnuson, The Synthesis of Aminoiminoethanenitriles, 5-Aminotetrazoles, N-Cyanoguanidines, and N-Hydroxyguanidines from Aminoiminomethanesulfonic Acids Synthetic Communications. ,vol. 20, pp. 217- 226 ,(1990) , 10.1080/00397919008052286
Audrey E. Miller, Judith J. Bischoff, A facile conversion of amino acids to guanidino acids Synthesis. ,vol. 1986, pp. 777- 779 ,(1986) , 10.1055/S-1986-31777
H. Arold, H. Feist, K. Wilding, Peptide, XII. Synthese eines linearen Dekapeptids mit potentieller modifizierter Circulin-Sequenz Journal Fur Praktische Chemie-chemiker-zeitung. ,vol. 311, pp. 511- 519 ,(1969) , 10.1002/PRAC.19693110322
John J. Nestor, Ram Tahilramani, Teresa L. Ho, Georgia I. McRae, Brian H. Vickery, Potent, long-acting luteinizing hormone-releasing hormone antagonists containing new synthetic amino acids: N,N'-dialkyl-D-homoarginines Journal of Medicinal Chemistry. ,vol. 31, pp. 65- 72 ,(1988) , 10.1021/JM00396A011
John J. Nestor, Teresa L. Ho, Richard A. Simpson, Bonnie L. Horner, Gordon H. Jones, Georgia I. McRae, Brian H. Vickery, Synthesis and biological activity of some very hydrophobic superagonist analogues of luteinizing hormone-releasing hormone. Journal of Medicinal Chemistry. ,vol. 25, pp. 795- 801 ,(1982) , 10.1021/JM00349A006
Peter Marfey, Determination ofD-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene Carlsberg Research Communications. ,vol. 49, pp. 591- 596 ,(1984) , 10.1007/BF02908688
Timothy Jen, Helene Van Hoeven, William Groves, Richard A. McLean, Bernard Loev, Amidines and related compounds. 6. Structure-activity relations of antihypertensive and antisecretory agents related to clonidine Journal of Medicinal Chemistry. ,vol. 18, pp. 90- 99 ,(1975) , 10.1021/JM00235A020
Robert Schwyzer, Antigone Costopanagiotis, Peter Sieber, 95. Zwei Synthesen des α-Melanotropins (α-MSH) mit Hilfe leicht entfernbarer Schutzgruppen) Helvetica Chimica Acta. ,vol. 46, pp. 870- 889 ,(1963) , 10.1002/HLCA.19630460319
Wilding K, Arold H, Feist H, ペプチド XII 修飾されたサーキュリン配列をもつ線状デカペプチド類の合成 Journal Fur Praktische Chemie-practical Applications and Applied Chemistry. ,vol. 311, pp. 511- 519 ,(1969)