A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration.

摘要: The vagus nerve plays a role in the cross talk between brain and gut microbiota, which could be involved depression. subdiaphragmatic serves as major modulatory pathway microbiota. Here, we investigated effects of vagotomy (SDV) on depression-like phenotype abnormal composition microbiota mice after lipopolysaccharide (LPS) administration. LPS caused phenotype, inflammation, increase spleen weight, downregulation synaptic proteins medial prefrontal cortex (mPFC) sham-operated mice. In contrast, did not produce downregulated mPFC SDV. weight plasma levels pro-inflammatory cytokines SDV + LPS group were lower than those sham + LPS group. Interestingly, there positive correlations suggesting relationship inflammatory events weight. Furthermore, led to significant alterations diversity mice, but SDV-operated an unweighted UniFrac PCoA, dots representing located far away from other three groups. Our results suggest that produces increases triggers downregulates mPFC, leads via nerve. It is likely crucial brain–gut–microbiota axis.