Choice strategies in Drosophila are based on competition between olfactory memories

摘要: The brain mechanisms by which animals deal with multiple experiences to predict outcomes are not yet fully understood. We explored the choice strategies that flies use assess degrees of disadvantage, as well how weigh past and recent guide decisions. Drosophila were exposed two conditioning events in a T-maze: an odor paired electric shock followed second different intensity. Subsequently, forced choose between odors. found chose avoid more 'dangerous' linear subtraction mechanism was based on coexisting memories. also weighed same danger level (60 V shocks) according times when had occurred. More greater impact gradually became 'overlooked' during decisions time delay lengthened. However, memory so much disrupted it overshadowed memories Finally, experience disadvantageous, wild-type able coordinate both temporal factor degree disadvantage into their By contrast, amnesiac mutant made choices completely factor, ignoring disadvantage. Taken together, store olfactory can coherently evaluate learned and/or factor.