Diagnostic and Prognostic Value of Circulating MicroRNAs for Esophageal Squamous Cell Carcinoma: a Systematic Review and Meta-analysis.

摘要: Background and Aim: MicroRNAs, dysregulated in the circulation of esophageal squamous cell carcinoma (ESCC) patient, have been assumed to be with great potential diagnosis prognosis cancer. We aimed review previous articles on ESCC. Methods: A search electronic databases was performed before Nov 12, 2017. summarized identification microRNA imbalance blood ESCC compared healthy controls, objective evaluate efficiency microRNAs diagnosing forecasting Results: total 35 studies investigating plasma or serum were included meta-analysis. Based consequences quality assessment each study, involved appropriate for quantitative synthesis. For diagnostic The overall pooled sensitivity, specificity, area under curve circulating is 0.794 (95% CI: 0.765 - 0.820), 0.779 (95%CI: 0.746 0.808), 0.86 0.82 0.88). value calculated respectively. prognostic meta-analysis, hazard ratios higher expression 1.34 1.14-1.58), which could significantly predict poorer survival Conclusions: Circulating distinguish patients from controls high sensitivity other invasive currently used screening methods. Simultaneously, there