Vulnerable Plaque Relation of Characteristics to Degree of Stenosis in Human Coronary Arteries

摘要: Background The microanatomic features of the atherosclerotic plaque at risk disruption include a large lipid core, high macrophage content, and thin cap. relation between core size, cap thickness either with each other or degree stenosis has yet to be evaluated in human coronary arteries. Methods Results Atherosclerotic plaques (n=160) were obtained from 31 subjects who died suddenly ischemic heart disease. In arteries perfused formol saline pressure 100 mm Hg, was measured by comparison minimal lumen size site that an adjacent normal segment artery. Plaque histological sections. Lipid ranged 0% 82% overall size. Seventeen percent had >50%. Linear regression showed no ( r =.21). Absolute bore =.14). Minimal not related =.06). Ten predicted angiographically invisible cores Conclusions Two major determinants vulnerability, thickness, are statistically related. Neither these two factors confer vulnerability absolute stenosis.