Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface

摘要: The vascular network of the brain is formed by invasion sprouts from pia mater toward ventricles. Following angiogenesis primary network, vessels experience a maturation process known as barriergenesis, in which blood–brain barrier formed. In this minireview, we discuss processes and well molecular cellular mechanisms underlying vessel formation. At level, barriergenesis occur via coordinated action oxygen-responsive molecules (e.g. hypoxia-inducible factor Src-suppressed C kinase substrate/AKAP12) soluble factors endothelial growth angiopoietin-1), axon guidance neurotrophic factors. focus on neurovascular cells, such pericytes, astrocytes, smooth muscle neurons macrophages. Each cell type plays unique role, works with other types to maintain environmental homeostasis respond certain stimuli. Taken together, minireview emphasizes importance cells at interface, regards regulation barriergenesis.