Determination of estrogen receptors in aspirates from needle biopsies of breast carcinomas. Correlation to a biochemical method

摘要: Several methods exist for determining oestrogen receptor status in breast carcinomas. Biochemical have been widely used many years, but recently immunocytochemical become available. We compared the outcome of biochemical and immunocytological analysis 274 cancer patients. Fine needle aspirates from all patients were investigated immunocytologically 214 tumours positive (78%) 60 negative (22%). data available 155 patients, concordance between two was 88%. Most 119 carcinomas (43%) that only cytologically too small to allow both histological analysis. A minority not operated on because high age, and/or impaired health, or tumour inoperable. In our opinion, are equally sensitive specific detecting tissue. fine there is additional advantage morphological assessment malignant nuclei possibility obtaining material lesions.