Impact of depressive mixed state in an emergency psychiatry setting: A marker of bipolar disorder and a possible risk factor for emergency hospitalization

摘要: Abstract Background Depressive mixed state (DMX) has been reported to be one of the most useful clinical markers for bipolar II disorder (BP-II) in outpatient setting. However, significance DMX emergency psychiatry not well studied. Methods A chart review study 139 patients who were hospitalized an psychiatric ward with initial diagnosis major depressive (MDD). Results In 42 (30.2%) patients, was changed after a median observation period 189 days from hospitalization, and these, 34 diagnosed as having BP-II. observed 56 (40.3%) at time hospitalization. Compared remained MDD, significantly more later developed had experienced (59.5% vs. 32.0%, p  = 0.0044). multivariate analysis, independent predictors conversion (OR 2.45,  = 0.037), chronic depression atypical features 2.85,  = 0.010; OR 3.67,  = 0.046, respectively). addition, frequently hospitalization than non-emergency (48.6% 29.1%,  = 0.0065). Limitations single reviewer evaluated by review. Conclusion is marker (mainly BP-II) setting closely related mood disorders. To confirm these findings, prospective that systematically evaluates needed.