Antiproteinuric effect of RAS blockade: new mechanisms.
作者： Markus Lassila , Mark E Cooper , Karin Jandeleit-Dahm , None
DOI: 10.1007/S11906-004-0058-9
关键词:
摘要: Experimental and clinical studies have shown that blockade of the renin-angiotensin system (RAS) is effective in reducing proteinuria conditions such as diabetes by systemic intraglomerular hydrostatic pressure. However, increasing evidence suggests nonhemodynamic effects, preservation podocyte slit diaphragm structure function, may also mediate antiproteinuric effects RAS blockade. In this review, we analyze detail for known novel mechanisms considered to play important roles mediating effect blockers, with a particular focus on diabetic nephropathy.
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