A Current Overview of Regulatory RNAs in Staphylococcus Aureus

摘要: Staphylococcus aureus is a common commensal bacterial species that usually found in the nose and on skin of 30 % healthy adults. However, bacterium remarkably versatile pathogen one main causes community as well hospital-acquired infections (Cheung et al., 2004; Novick, 2003). S. responsible for systemic such sepsis endocarditis, which can be difficult to treat due acquisition resistance towards numerous antibiotics clinical use. wide spectrum human diseases part its ability produce an array virulence factors, are mostly encoded by laterally acquired genomic regions, so-called pathogenicity islands. These factors include surface proteins adhesion invasion host, exoproteins required host immune evasion, toxins involved dissemination tissues nutrients (Novick, Redundancies exist ensure productive infection still occurs even though factor may lost. In recent decades, many studies have been carried out understand how able coordinate expression large panel at appropriate time order facilitate successful (Novick Geisinger, 2008). works offer possibility developing anti-virulence therapies alternative strategies affecting bacteria viability, i. e. inhibiting cause damage or interaction between (Clatworthy 2007). Inhibiting instead viability little impact flora result weaker selective pressure development antibiotic resistance. Hence, determining regulatory networks dynamics fast adaptive responses prime importance combating infections.