Balanced approach of γδ T cells to type 2 immunity

作者: Willi K Born , Yafei Huang , Niyun Jin , Hua Huang , Rebecca L O'Brien

DOI: 10.1038/ICB.2009.105

关键词:

摘要: Substantial evidence has been accumulated to indicate that gammadelta T cells take part in type 2 immune responses. It is not yet clear, however, what capacity. Apparently, themselves can only the function of follicular helper (T(H)) certain responses, but also support responses are dependent on classical help provided by alphabeta cells. Furthermore, engage as regulators T(H2) immunity. Here, we consider two mouse models depend immunity, non-specific airway hyperresponsiveness methacholine after allergen inhalation challenge and primary IgE response induced alum-aided immunization, examine In either case, regulate immunity through balanced enhancing inhibitory influences. However, exposure, suppressive become dominant. The underlying mechanisms discussed.

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