Clinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer.

摘要: Introduction Young-onset colorectal cancer is recognized as a distinct disease that may be sporadic or hereditary in nature. Microsatellite instability testing recommended routine procedure evaluating specimens, especially young-onset disease, because of implications management. Immunohistochemistry mismatch repair proteins serves an inexpensive alternative to microsatellite with the added advantage monitoring protein expression levels suggest underlying genetic epigenetic alterations. This descriptive study aimed determine frequencies proficient and deficient status among Filipino patients, investigate their clinicopathologic profile. Methods Tumor tissues were prospectively collected from patients two tertiary hospitals Philippines. Patients age ≤45 years resected adenocarcinoma colon rectum recruited. Results Seventy-seven out 124 had tumor samples sent for immunohistochemistry. Of these, 61 (79%) found have while 16 (21%) status. Mismatch deficiencies, when present, more commonly involved MSH2 MSH6 (9%) rather than MLH1 PMS2 (5%). The group mean 37.1 female preponderance (56.25%), presenting locally advanced ascending descending tumors mucinous histology half population. presented rectal sigmoid but fewer adenocarcinomas (26.2%) compared group. In both family history reports, most did not any known relative (75.4% 68.75%, respectively). Conclusion first attempt perform Philippines gather data on characteristics. However, limited sample size precludes conclusive results associations features.