Rules of Evidence and Clinical Recommendations on the Use of Antithrombotic Agents

摘要: W hat n~les of evidence should apply when evpert committees meet to generate recommendations for the clinical management patients? Should only thoroughly validated results randomized trials be admissible avoid or minimize application useless harmful therapy? Or, maximize potential benefits patients (inclr~ding those possible from unproved remedies), a synthesis experiences experienced clinicians form basis such recommendations? Ample precedent exists latter approach even attempts are made replace it.' However, following reasons, nonexperimental that forms recalled seasoned will tend overestimate efficacy: