Studies on colonization and infection with Staphylococcus aureus and other microbes in skin disease

摘要: The skin is colonized with a wide range of microbes. Some offer vital protection from colonization and infection pathogenic strains while others have the capacity to cause or exacerbate disease. aim this thesis was investigate role management microbes found on affected by three disorders; balanoposthitis, impetigo atopic dermatitis (AD). Paper I investigates frequency distribution bacteria, Candida Malassezia species in common inflammatory and/or infectious disorder prepuce glans penis. Patients balanoposthitis were more often than control group. Specifically, S. aureus 19% patients not at all There no significant increase balanoposthitis. Different clinical manifestations did predict presence specific association seborrhoeic psorisasis. II describes bacterial spectrum proportion fusidic acid-resistant (FRSA) cultures lesional secondarily infected AD. most frequent finding (76-93%) acid-resistance 75%, 32% 6.1% isolates form bullous impetigo, non-bullous AD, respectively. In paper III vitro antimicrobial activity topical pharmaceuticals tested against aureus, epidermidis, Streptococcus pyogenes, Escherichia coli albicans. Formulations clioquinol, halquinol hydrogen peroxide had broad effect. azole class antifungal formulations an anti-staphylococcal IV variations relation severity AD (assessed SCORAD) adult during 5-month follow-up. High density skin, multiple body sites persistent one strain associated severe Conclusion: Balanoposthitis increased potentially primary therapeutic target mild moderate cases without overt signs should be decrease inflammation microbial load corticosteroid-antimicrobial combination. FRSA are but remained relatively infrequent Use promotes spread resistant avoided. Topical non-resistance-promoting anti-septic could useful superficial infections help reduce use systemic antibiotic treatment. Detailed investigation different aspects can understanding complex aureus-AD interaction possible value interventions clinically non-infected Keywords: balanoposhtitis; microbes; Staphylococcus aureus; Candida; Malassezia; acid; impetigo; dermatitis; azoles; clioquinol; halquinol; peroxide; infection; SCORAD ISBN: 978-91-628-8565-6 Gothenburg 2012