GABRA2 markers moderate the subjective effects of alcohol

作者: Magdalena Uhart , Elise M. Weerts , Mary E. McCaul , Xiuqing Guo , Xiaofei Yan

DOI: 10.1111/J.1369-1600.2012.00457.X

关键词:

摘要: Background Individual differences in subjective responses to alcohol (SR) are moderated by genetic variants and may be risk factors for the development of use disorders. Variation GABAA α2 receptor subunit gene (GABRA2) has been associated with dependence (AD). Therefore, we examined whether individual SR, which reflect sensitivity effects alcohol, variation GABRA2.

参考文章(50)
Gillian C.L. Johnson, Laura Esposito, Bryan J. Barratt, Annabel N. Smith, Joanne Heward, Gianfranco Di Genova, Hironori Ueda, Heather J. Cordell, Iain A. Eaves, Frank Dudbridge, Rebecca C.J. Twells, Felicity Payne, Wil Hughes, Sarah Nutland, Helen Stevens, Phillipa Carr, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Stephen C.L. Gough, David G. Clayton, John A. Todd, Haplotype tagging for the identification of common disease genes Nature Genetics. ,vol. 29, pp. 233- 237 ,(2001) , 10.1038/NG1001-233
Verena Tretter, Noosha Ehya, Karoline Fuchs, Werner Sieghart, Stoichiometry and Assembly of a Recombinant GABAA Receptor Subtype The Journal of Neuroscience. ,vol. 17, pp. 2728- 2737 ,(1997) , 10.1523/JNEUROSCI.17-08-02728.1997
Patrick D. Quinn, Kim Fromme, Subjective Response to Alcohol Challenge: A Quantitative Review Alcoholism: Clinical and Experimental Research. ,vol. 35, pp. 1759- 1770 ,(2011) , 10.1111/J.1530-0277.2011.01521.X
Sungwon Roh, Sachio Matsushita, Sachiko Hara, Hitoshi Maesato, Toshifumi Matsui, Go Suzuki, Tomohiro Miyakawa, Vijay A. Ramchandani, Ting-Kai Li, Susumu Higuchi, Role of GABRA2 in Moderating Subjective Responses to Alcohol Alcoholism: Clinical and Experimental Research. ,vol. 35, pp. 400- 407 ,(2011) , 10.1111/J.1530-0277.2010.01357.X
Mary-Anne Enoch, Lori Schwartz, Bernard Albaugh, Matti Virkkunen, David Goldman, Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. American Journal of Medical Genetics. ,vol. 141, pp. 599- 607 ,(2006) , 10.1002/AJMG.B.30336
Richard W. Olsen, Harry J. Hanchar, Pratap Meera, Martin Wallner, GABAA receptor subtypes: the “one glass of wine” receptors Alcohol. ,vol. 41, pp. 201- 209 ,(2007) , 10.1016/J.ALCOHOL.2007.04.006
M A Schuckit, Self-rating of alcohol intoxication by young men with and without family histories of alcoholism. Journal of Studies on Alcohol and Drugs. ,vol. 41, pp. 242- 249 ,(1980) , 10.15288/JSA.1980.41.242
Jonathan Covault, Joel Gelernter, Victor Hesselbrock, Maggie Nellissery, Henry R. Kranzler, Allelic and haplotypic association of GABRA2 with alcohol dependence American Journal of Medical Genetics. ,vol. 129, pp. 104- 109 ,(2004) , 10.1002/AJMG.B.30091
Howard J. Edenberg, Danielle M. Dick, Xiaoling Xuei, Huijun Tian, Laura Almasy, Lance O. Bauer, Raymond R. Crowe, Alison Goate, Victor Hesselbrock, Kevin Jones, Jennifer Kwon, Ting-Kai Li, John I. Nurnberger, Sean J. O’Connor, Theodore Reich, John Rice, Marc A. Schuckit, Bernice Porjesz, Tatiana Foroud, Henri Begleiter, Variations in GABRA2, Encoding the α2 Subunit of the GABAA Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations American Journal of Human Genetics. ,vol. 74, pp. 705- 714 ,(2004) , 10.1086/383283
Marc A Schuckit, Chiara Mazzanti, Tom L Smith, Umbereen Ahmed, Marta Radel, Nakao Iwata, David Goldman, Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABAα6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study Biological Psychiatry. ,vol. 45, pp. 647- 651 ,(1999) , 10.1016/S0006-3223(98)00248-0