CREB Signaling in Neural Stem/Progenitor Cells: Implications for a Role in Brain Tumors

摘要: Since its discovery in the PC12 rat pheochromocytoma cell line (Montminy & Bilezikjian 1987) cAMP Response Element Binding (CREB) protein has been implicated a variety of neuronal responses such as excitation, long-term memory formation, neural proliferation and opiate tolerance. Its importance is underscored by attention this factor attracted neuroscience community, evidenced thousands citations academic bibliographic databases. CREB transcription which potentially regulates hundreds or even genes neurons. A kinases possess capability driving phosphorylation activation, placing at hub multiple intraneuronal signalling cascades. The array functions attributed to expanded recently, with studies showing that role stem/progenitor growth, differentiation survival. This data, together complementary tissues outside CNS activation oncogenic effects led hypothesis an important brain tumour biology. Therefore, sits within molecular network integrating events regulating stem cells neurogenesis, cancer other tumors.