Heat shock proteins and the biogenesis of cellular membranes.

摘要: The successful function of cells is importantly contributed by lipid membranes that are more than a simple physical barrier. major components cellular lipids, in particular glycerophospholipids, have the capacity to assemble spontaneously into vesicles containing bilayer after exposure an aqueous milieu due their amphiphilic characteristics. form and encapsulate substrates has been proposed as fundamental event during biogenesis cells. However, stability small compromised expansion larger complex particles. Recent observations (Cornell et al. Proc Natl Acad Sci U S A 116:17239-17244, 2019) shown insertion amino acids rudimentary could play stabilizing role was critical formation early Fatty were likely substituted glycerophospholipids replaced polypeptides evolution protocells. Thus, archaic peptides displaying lipid-binding membrane-penetrating capacities played key development current In this regard, heat shock proteins (HSP), particularly Hsp70 (HSPA) HSP (HSPB) families, portrayed role. Indeed, bacterial DnaK closest sequence earliest members family inserts spontaneously. Moreover, extensive studies Vigh group that, certainly, Hsp70s stabilize membranes. ability ancestral HSP70s HSPs associate with lipids genesis