Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development.

摘要: The labial (lab) gene of Drosophila melanogaster is necessary for the proper development embryonic (larval) and adult head. We have identified lab transcription unit within proximal portion Antennapedia Complex (ANT-C) by mapping molecular lesions associated with chromosomally rearranged alleles. present its structure, nucleotide sequence, temporal pattern expression. In addition, using antibodies generated against a fusion protein, we show that in embryo protein distributed neural epidermal cells procephalic lobe; discrete loop midgut; specific progenitor sensory clypeolabrum, thoracic segments, tail region. regions expression developing cephalon represent nonsegmented domains are anterior to largely nonoverlapping Deformed (Dfd) proboscipedia (pb) genes, two other homeotic loci ANT-C also function direct head structures. Furthermore, complex cellular movements involution, process not only defective embryos, but failure which appears be responsible defects observed mutant embryos. Finally, suggest provides marker an intercalary segment, ancestral segment has become morphologically indistinct during evolution insect