Enzyme activities and morphological appearance in functioning and excluded segments of the small intestine after shunt operation for obesity.

摘要: Five patients in whom small-intestinal bypass was performed for severe obesity had a second operation 11-19 months later because of insufficient weight loss. Mucosal enzyme activities and histological appearance were investigated biopsies from different parts the functioning excluded small intestine. These compared with form corresponding sites obtained at first operation. In addition to prominent increase length, circumference, mucosal thickness shunt, disaccharidases two intracellular beta-galactosidases increased specific activity,, especially distal ileal part shunt. segment intestine enzymes showed response: trehalase alkaline phosphate decreased significantly. Other that measured varied pattern. The results indicated not only luminal content but also other, presumably hormonal, factors regulated activities, regulating influenced various differently. marked adaptive surface shunt could be one factor explaining stabilisation and, some cases, after initial rapid loss bypass. would further digestive capacity