Molecular markers for prognosis after isolated postmastectomy chest wall recurrence.

摘要: BACKGROUND Local chest wall recurrence after mastectomy occurs in 10–20% of patients with operable breast carcinoma. The objective the current study was to assess prognostic value molecular markers at time local and compare these clinical variables. METHODS Between 1975 1999, authors treated 113 their institution for postmastectomy recurrences full-course external beam radiotherapy. Patients who presented primarily lymph node or simultaneous distant metastasis were excluded. Follow-up from 10.13 years. All pathologic data original diagnosis entered into a computerized database. Paraffin-embedded tumor specimens available 43 constructed tissue microarrays immunohistochemical staining estrogen receptor, progesterone receptor (PR), p53, HER-2/neu, cyclin D. RESULTS Overall survival entire cohort 46% 5 years 28% 10 metastasis–free rate 49% 40% Local-regional control disease achieved 79% In multivariate analysis, significant factors (< 2 recurrence) PR status (distant rate: 84% [PR-positive] vs. 38% [PR-negative]; P = 0.007). only factor local-regional progression HER-2/neu status. positive had progression-free 59%, compared 92% negative status. CONCLUSIONS The prognosis carcinoma is relatively poor. Longer associated favorable rates long-term survival. Positive poorer disease. Implications systemic therapy further studies are discussed. Cancer 2004;100:252–63. © 2003 American Society.