Role of cholecystokinin in the regulation of gastrointestinal motility

摘要: Cholecystokinin, a hormone released from endocrine cells of the upper small intestine in response to amino acids and fatty chyme, has potent effects on gut smooth muscle contractility. Depending region gut, effect cholecystokinin may be neurally mediated, direct, or both. Neurally-mediated relaxant contractile depending transmitter by cholecystokinin. Based mimicry infusion postprandial levels ability specific receptor antagonists abolish endogenous meal, three physiological cholecystokinin, all which are neurally-mediated, have been identified: contraction gallbladder mediated cholecystokinin-induced release acetylcholine, relaxation sphincter Oddi vasoactive intestinal peptide inhibition gastric emptying activation an inhibitory vago-vagal reflex involving peptide-induced fundus. Gallbladder regulate flow bile, regulates chyme into duodenum. Combined with stimulation pancreatic enzyme secretion these insure optimal conditions for digestion absorption nutrients intestine.