Heightened risk of early vocal fold motion impairment onset and dysphagia in the parkinsonian variant of multiple system atrophy: a comparative study

摘要: Abstract Objective We compared differences in frequency and timing of onset the following clinical events between cerebellar parkinsonian variants multiple system atrophy (MSA-C MSA-P, respectively): type operation including tracheostomy and/or aspiration prevention surgery, vocal fold motion impairment (VFMI), sleep apnea (SA), introduction mechanical ventilation (MV), dysphagia. The risks these cooccurring with either MSA-C or MSA-P were compared. Methods retrospectively assessed outcomes only patients MSA who presented at Department Otolaryngology University Tokyo Hospital 2008 2018. proportion using chi-square tests Cox proportional hazard models adjusted for age, sex, disease severity, respectively. Results identified 113 (median age: 60 years, 72 men [64%]). VFMI, SA, MV, dysphagia, surgeries 55 (49%) 76 (95% CI 61–91) months after onset, 85 (75%) 41 (32–50), 36 (32%) 100 (73–127), 77 (68%) 43 (36–50), 25 (22%) 102 (84–120), Twenty-seven (24%) had higher risk VFMI (p  Conclusion While is less common, it may involve heightened dysphagia early onset. Thus, careful follow-up be needed patients. Criteria Rating Diagnostic Accuracy Studies Class II.