Response of the Macrocirculation

摘要: Shock is the physiologic evidence of cellular demand for energy exceeding mitochondrial capability to generate adenosine triphosphate (ATP) aerobically. With notable exception septic shock, most forms shock result from decreases in systemic O2 transport (ṪO2) produced by loss circulatory volume and heart or respiratory failure. These conditions alter distribution cardiac output blood flow (Q) within individual organs. alterations are expression neural, humoral, local metabolic mechanisms vascular control that strive maintain adequate tissue perfusion vital organs, such as heart, brain, adrenal glands, skeletal muscle. Although our knowledge redistribution during incomplete, determinants organ disease examined this chapter.