Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?

摘要: Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains deficit: systematic biases favoring materials negative emotional valence; diminished access and response to positive memories; recollection overgeneral memories in detriment specific role ruminative processes avoidance when dealing with Furthermore, we evidence from functional neuroimaging studies neural circuits activated both healthy individuals. Disruptions predispose portend onset maintenance depression. Thus, discuss emerging therapeutics that target memory difficulties those strategies for this clinical domain, including specificity training, method-of-loci, rescripting, real-time fMRI neurofeedback training amygdala activity propose manipulation reconsolidation depression might represent novel yet largely unexplored, domain-specific, therapeutic opportunity treatment.